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Tuesday 8 May 2018

Definition: Recurrent mutations in histone genes can cause pediatric cancers. These mutations occur at high frequency and lead to the expression of mutant histones that exhibit oncogenic features. Thus, they are termed oncohistones.

Mutations have been found in the genes encoding histone H3 and its variants.

The expression of the oncohistones affects the global chromatin landscape.

Paywall references

- Oncohistones: drivers of pediatric cancers. Mohammad F, Helin K. Genes Dev. 2017 Dec 1;31(23-24):2313-2324. doi : 10.1101/gad.309013.117 PMID: 29352018

- H3.1 K36M mutation in a congenital-onset soft tissue neoplasm. Kernohan KD, Grynspan D, Ramphal R, Bareke E, Wang YC, Nizalik E; Care4Rare Canada Consortium, Ragoussis J, Jabado N, Boycott KM, Majewski J, Sawyer SL. Pediatr Blood Cancer. 2017 Dec;64(12). doi : 10.1002/pbc.26633 PMID: 28509377