Home > D. Systemic pathology > Hematopathology > fibrin-ring granuloma

fibrin-ring granuloma

Monday 29 December 2003

Definition: Fibrin ring or "doughnut" granulomas are small, non-necrotizing granulomas with a very distinctive appearance that are usually found in the liver and bone marrow in patients with Q fever. These granulomas characteristically contain a ring-like structure consisting of fibrinoid material; they may or may not have a centrally located fat vacuole(s).

Etiology

- rickettsiosis

  • Q fever (Coxiella burnetti)
  • boutonneuse fever
  • staphylococcal infection
  • Lyme disease

- viral infections

  • cytomegalovirus infection (CMV infection)
  • hepatitis A
  • Epstein-Barr virus infections (EBV infections)
    • infectious mononucleosis

- protozoal infections

  • visceral leishmaniasis
  • disseminated toxoplasmosis

- drug reactions

  • allopurinol hypersensitivity

- dysimmune diseases

  • systemic lupus erythematosus
  • giant-cell arteritis

- tumors

  • Hodgkin lymphomas
  • non-Hodgkin lymphomas

See also

- Granulomas