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fibrin-ring granuloma

Monday 29 December 2003

fibrin ring granuloma, doughnut granuloma

Definition: Fibrin ring or "doughnut" granulomas are small, non-necrotizing granulomas with a very distinctive appearance that are usually found in the liver and bone marrow in patients with Q fever. These granulomas characteristically contain a ring-like structure consisting of fibrinoid material; they may or may not have a centrally located fat vacuole(s).

Localization

- hepatic fibrin-ring granuloma
- medullary fibrin-ring granuloma

Etiology

- rickettsiosis

  • Q fever (Coxiella burnetti )
  • boutonneuse fever
  • staphylococcal infection
  • Lyme disease

- viral infections

- protozoal infections

- drug reactions

- dysimmune diseases

- tumors

See also

- granulomas