Home > D. Systemic pathology > Hematopathology > fibrin-ring granuloma
fibrin-ring granuloma
Monday 29 December 2003
Definition: Fibrin ring or "doughnut" granulomas are small, non-necrotizing granulomas with a very distinctive appearance that are usually found in the liver and bone marrow in patients with Q fever. These granulomas characteristically contain a ring-like structure consisting of fibrinoid material; they may or may not have a centrally located fat vacuole(s).
Etiology
rickettsiosis
- Q fever (Coxiella burnetti)
- boutonneuse fever
- staphylococcal infection
- Lyme disease
viral infections
- cytomegalovirus infection (CMV infection)
- hepatitis A
- Epstein-Barr virus infections (EBV infections)
- infectious mononucleosis
protozoal infections
- visceral leishmaniasis
- disseminated toxoplasmosis
drug reactions
- allopurinol hypersensitivity
dysimmune diseases
- systemic lupus erythematosus
- giant-cell arteritis
tumors
- Hodgkin lymphomas
- non-Hodgkin lymphomas
See also
Granulomas
