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ARNT2

Monday 20 November 2017

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Definition: Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors.

The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli.

Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes.

A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.

Pathology

- ARNT2 is at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness. (29149419)

- ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma.
(27076852)

- ARNT2 mutation causes hypopituitarism, post-natal microcephaly, visual and renal anomalies. (24022475)

References

- Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness.
Bogeas A, Morvan-Dubois G, El-Habr EA, Lejeune FX, Defrance M, Narayanan A, Kuranda K, Burel-Vandenbos F, Sayd S, Delaunay V, Dubois LG, Parrinello H, Rialle S, Fabrega S, Idbaih A, Haiech J, Bi├Ęche I, Virolle T, Goodhardt M, Chneiweiss H, Junier MP.
Acta Neuropathol. 2017 Nov 17. doi : 10.1007/s00401-017-1783-x
PMID: 29149419

- ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma.
Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.
J Cancer. 2016 Mar 26;7(6):702-10. doi : 10.7150/jca.14208. eCollection 2016
PMID: 27076852