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sclerosing polycystic adenosis/adenoma

Monday 26 June 2017


Definition: SPA is a rare sclerosing tumor of the salivary glands characterized by the combination of cystic ductal structures with variable cell lining including vacuolated, apocrine, mucinous, squamous, and foamy cells, by prominent large acinar cells with coarse eosinophilic cytoplasmic zymogen-like granules, and by closely packed ductal structures, surrounded by a peripheral myoepithelial layer and stromal fibrosis with focal inflammatory infiltrates.

SPA frequently harbors intraductal epithelial dysplastic proliferations ranging from mild dysplasia to severe dysplasia/carcinoma in situ.

SPA has been proven to be a clonal process by HUMARA assay and is associated with considerable risk of recurrence.

SPA is likely a neoplasm, and the name "sclerosing polycystic adenoma" has been suggested.

Paywall references

Newly Described Entities in Salivary Gland Pathology.
Skálová A, Gnepp DR, Lewis JS Jr, Hunt JL, Bishop JA, Hellquist H, Rinaldo A, Vander Poorten V, Ferlito A.
Am J Surg Pathol. 2017 Jun 13. doi : 10.1097/PAS.0000000000000883
PMID: 28614209