Home > D. Systemic pathology > Hematopathology > Rosai-Dorfman disease

Rosai-Dorfman disease

Tuesday 16 December 2003

Ent. 1969.

Digital cases

- HPC:290

Localization

- lymph node (nodal Rosai-Dorfman disease)
- extranodal Rosai-Dorfman disease

Types

- mostly isolated
- rarely multicentric (12622452)

Synopsis

- large, pale, histiocytic cells (Rosai-Dorfman cells) exhibiting emperipolesis (cytophagocytosis)

Immunohistochemistry

- S-100+
- CD68+
- CD1a-

Electron microscopy

- Birbeck granules are absent

Associations

- acute lymphoblastic leukemia (11496358#)
- lymphoma (9031615, 9006752)
- follicular lymphoma (10786808)
- nodular lymphocyte predominant Hodgkin disease (10786808, 8522313)
- chronic autoimmune thyroiditis (10710276)
- inflammatory pseudotumor (9059366)
- systemic lupus erythematosus (11555773)

References