Friday 21 April 2017
The proteostasis network (PN) regulates protein synthesis, folding, transport, and degradation to maintain proteome integrity and limit the accumulation of protein aggregates, a hallmark of aging and degenerative diseases.
Proteome integrity is maintained by the proteostasis network (PN), which consists of interconnected systems that regulate protein synthesis, folding, transport, and degradation in every cell.
The functionality of this network declines during aging, thus compounding the risk for diseases related to proteostasis dysfunction, such as neurodegenerative diseases, cardiomyopathies, and metabolic disorders.
Multicellular organisms, however, consist of different cell types that are structurally and functionally diverse, reflecting distinct proteomes.
Differentiation, specialization, and spatial organization of cells in complex organisms also influence the ability of individual cells to sense and respond to stressful stimuli.
It involves the differential scales of proteostasis regulation from the cellular to the organismal level and discuss implications for human health.
Shaping proteostasis at the cellular, tissue, and organismal level. 2017. doi : 10.1083/jcb.201612111 Free paper