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EWSR1-associated myxoid mesenchymal tumor

Thursday 16 March 2017

Recurrent gene fusions involving EWSR1 with members of the cAMP response element binding protein ( CREBs ) family (ATF1 and CREB1) have been reported in a diverse group of tumors including angiomatoid fibrous histiocytoma (AFH), soft tissue and gastrointestinal clear cell sarcoma, primary pulmonary myxoid sarcoma, and hyalinizing clear cell carcinoma of salivary gland.


- EWSR1 Fusions With CREBs Family Transcription Factors ( ATF and CREB1 ) Define a Novel Myxoid Mesenchymal Tumor With Predilection for Intracranial Location. Kao YC, Sung YS, Zhang L, Chen CL, Vaiyapuri S, Rosenblum MK, Antonescu CR. Am J Surg Pathol. 2017 Apr;41(4):482-490. doi : 10.1097/PAS.0000000000000788 PMID: 28009602