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multiple familial trichoepithelioma

Friday 3 March 2017


Multiple familial trichoepithelioma (MFT) is an autosomal dominant disorder of skin appendage tumors characterized by the appearance of trichoepitheliomas.

- MFT1

  • Multiple familial trichoepithelioma-1 (MFT1) is caused by heterozygous mutation in the CYLD gene (MIM.605018) on chromosome 16q12.
  • Allelic disorders with overlapping features include familial cylindromatosis (MIM.132700) and Brooke-Spiegler syndrome (BRSS; MIM.605041).

- MFT2 (MIM.612099) has been mapped to 9p21.

See also

- trichoepithelioma