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DNA repair genes

Thursday 9 February 2017

DRGs; DNA repair proteins

Pathology - Examples

- BRCA1-associated prostatic adenocarcinoma
- BRCA2-associated prostatic adenocarcinoma
- ATM-associated prostatic adenocarcinoma

The carrier rate of germline BRCA1/2 and ATM mutation was ∼5-fold higher in lethal prostate cancer patients than in localized prostate cancer patients. doi : 10.1016/j.eururo.2016.11.033

Mutation carriers of BRCA1/2 and ATM are associated with earlier age at death and shorter survival time. doi : 10.1016/j.eururo.2016.11.033

Open references

- Genomic landscape of DNA repair genes in cancer.
Chae YK, Anker JF, Carneiro BA, Chandra S, Kaplan J, Kalyan A, Santa-Maria CA, Platanias LC, Giles FJ.
Oncotarget. 2016 Apr 26;7(17):23312-21. doi : 10.18632/oncotarget.8196
PMID: 27004405 Free

- DNA repair genes implicated in triple negative familial non-BRCA1/2 breast cancer predisposition.
Ollier M, Radosevic-Robin N, Kwiatkowski F, Ponelle F, Viala S, Privat M, Uhrhammer N, Bernard-Gallon D, Penault-Llorca F, Bignon YJ, Bidet Y.
Am J Cancer Res. 2015 Jun 15;5(7):2113-26.
PMID: 26328243 Free

- Epigenetic changes of DNA repair genes in cancer.
Lahtz C, Pfeifer GP.
J Mol Cell Biol. 2011 Feb;3(1):51-8. doi : 10.1093/jmcb/mjq053. Review
PMID: 21278452 Free