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Kaposi sarcoma

Friday 12 December 2003

Digital cases

- HPC:28 : Kaposi sarcoma
- UI:488 - cutaneous Kaposi sarcoma.
- JRC:10989 : Kaposi sarcoma.
- JRC:11011 : Kaposi sarcoma.
- Kaposi sarcoma of skin of the skin on Flick by ddkri

Definition: In the OMS classification (2004), Kaposi sarcoma was moved into the category of intermediate vascular tumors (rarely metastasizing) in order to reflect continuing ambiguity as to the precise biological nature of this lesion.

This is a multifocal HHV-8-driven vascular proliferation which does not show conventional features of malignancy—in particular, it may regress spontaneously.

It shows relative sparing of certain tissues such as brain, kidney and skeletal muscle, is most often diploid, is very difficult to transplant/xenograft and does not appear to show any conventional pattern of metastasis.

Etiology

- Human herpesvirus-8 (HHV-8) infection is considered the initiating factor in all forms of Kaposi sarcoma (KS)

Cytogenetics

- No consistent abnormality

See also

- Tumors

  • soft tissue tumors
    • vascular tumors

References

- Verschuren EW, Jones N, Evan GI. The cell cycle and how it is steered by Kaposi’s sarcoma-associated herpesvirus cyclin. J Gen Virol. 2004 Jun;85(Pt 6):1347-61. PMID: 15166416

Portfolio

  • Pulmonary Kaposi sarcoma
  • Pulmonary Kaposi sarcoma
  • Pulmonary Kaposi sarcoma
  • Pulmonary Kaposi sarcoma
  • Pulmonary Kaposi sarcoma