Friday 12 December 2003
Definition: Kaposi sarcoma is a multifocal HHV-8-driven vascular proliferation which does not show conventional features of malignancy—in particular, it may regress spontaneously.
polypoid lesion : pyogenic granuloma-like Kaposi sarcoma (H&E, HHV-8).
micronodular growth in Kaposi sarcoma
promontory sign in Kaposi sarcoma
It shows relative sparing of certain tissues such as brain, kidney and skeletal muscle, is most often diploid, is very difficult to transplant/xenograft and does not appear to show any conventional pattern of metastasis.
Human herpesvirus-8 (HHV-8) infection is considered the initiating factor in all forms of Kaposi sarcoma (KS)
No consistent abnormality
- soft tissue tumors
- vascular tumors