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thyroid gland carcinomas

Friday 12 December 2003

thyroid carcinomas

Digital cases

- JRC:2665 : Follicular carcinoma (focal Hurthle cell features), minimally invasive .
- JRC:2667 : Poorly differentiated (insular) carcinoma .
- JRC:2668 : Thyroid medullary carcinoma, classical type .
- JRC:2663 : Thyroid medullary carcinoma, papillary variant .
- JRC:2669 : Anaplastic (squamous cell) carcinoma, arising from a preexisting Hurthle cell neoplasm .
- JRC:2670 : Thyroid medullary carcinoma, spindle cell variant .
- JRC:2672 : Thyroid anaplastic carcinoma, paucicellular variant .

Synopsis

- Mainly adults

Classification

- well-differentiated carcinomas of the thyroid

  • thyroid follicular carcinoma
  • thyroid papillary carcinoma
  • Hurthle cell thyroid carcinoma

- anaplastic carcinoma of the thyroid

According to age

- pediatric thyroid carcinomas

  • rare but well-reported in childhood
  • especially papillary carcinoma
  • increased rate with radiation exposure
  • tend to present with more advanced disease than adults with lymph node and lung metastases
  • have higher recurrence rates but better overall survival

Molecular biology

- expression profiling: 12738736, 12707638, 12480920

- cDNA libraries: 12480920

- CTNNB1 exon 3 mutations in poorly differentiated (25%) and undifferentiated thyroid carcinomas (21.4%) (11238046)

Predisposition

- familial thyroid cancers

References

- Alsanea O, Clark OH. Familial thyroid cancer. Curr Opin Oncol. 2001 Jan;13(1):44-51. PMID: 11148685

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