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serous endometrial intraepithelial carcinoma

Wednesday 7 December 2016

serous endometrial intraepithelial carcinoma (SEIC)

Uterine serous endometrial intraepithelial carcinoma (SEIC) is an immediate precursor of invasive carcinoma.

The majority of stage IA SEICs are curable, but those with latent peritoneal metastasis and/or capillary lymphatics invasion may have poor prognoses.

Careful pathologic staging is thus needed to predict the risk of recurrence and to determine postoperative therapeutic strategies.

Although SEICs confined to the uterine endometrium in most cases predict a good prognosis, microscopic metastasis to the peritoneum may not be detectable at hysterectomy.

If secondary malignancies of a serous phenotype develop years later, comprehensive reexamination of SEIC is mandated, with the help of DNA analysis.

Open references

- Metachronous serous endometrial intraepithelial carcinoma and serous peritoneal carcinoma: analysis of probable independent lesions.
Furuya M, Sato T, Tanaka R, Yamamoto M, Yokota NR, Miyagi E.
Diagn Pathol. 2016 Nov 14;11(1):130.
PMID: 27842566 Free

- https://www.jcgo.org/index.php/jcgo/article/view/446/300