Thursday 4 December 2003
The nucleolus is the dense globular mass of material within the nucleus. As the cell grows, one or more nucleoli may appear. Nucleoli are sites where the RNA subunits and ribosomes are assembled. These subunits are then shipped out of the nucleus into the cytoplasm where proteins can be synthesized and the functional ribosomes can attach to the rough ER.
assembling ribosomal subunits is well established
processing and modification of preribosomal RNA
sequestering regulatory molecules
modifying small RNAs
assembling ribonucleoprotein (RNP)
Olson MO, Dundr M, Szebeni A. The nucleolus: an old factory with unexpected capabilities. Trends Cell Biol. 2000 May;10(5):189-96. PMID: 10754561