Home > B. Cellular pathology > nucleolus

nucleolus

Thursday 4 December 2003

The nucleolus is the dense globular mass of material within the nucleus. As the cell grows, one or more nucleoli may appear. Nucleoli are sites where the RNA subunits and ribosomes are assembled. These subunits are then shipped out of the nucleus into the cytoplasm where proteins can be synthesized and the functional ribosomes can attach to the rough ER.

Function

- assembling ribosomal subunits is well established
- processing and modification of preribosomal RNA
- nuclear export
- sequestering regulatory molecules
- modifying small RNAs
- assembling ribonucleoprotein (RNP)
- controlling aging

References

- Thiry M, Lafontaine DL. Birth of a nucleolus: the evolution of nucleolar compartments. Trends Cell Biol. 2005 Apr;15(4):194-9. PMID: 15817375

- Olson MO, Dundr M, Szebeni A. The nucleolus: an old factory with unexpected capabilities. Trends Cell Biol. 2000 May;10(5):189-96. PMID: 10754561