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Home > E. Pathology by systems > Digestive system > Liver and pancreatobiliary system > intraepithelial neoplasia of pancreatobiliary tract

intraepithelial neoplasia of pancreatobiliary tract

Wednesday 19 October 2016

PTBIN; pancreatobiliary tract INs

tumoral and flat intraepithelial neoplasia

Tumoral intraepithelial neoplasia presents as an intraluminal or intraductal, mass-forming, polypoid lesion or a macroscopic, visible, cystic lesion without intracystic papillae.

Microscopically, tumoral intraepithelial neoplasia shows various proportions of papillary and tubular architecture, often with a mixed pattern, such as papillary, tubular, and papillary-tubular.

The malignant potential depends on the degree of dysplasia and the cell phenotype of the epithelium.

Flat intraepithelial neoplasia presents as a flat or superficial, spreading, mucosal lesion that is frequently accompanied by an invasive carcinoma.

Tumoral and flat intraepithelial neoplasias are not homogeneous entities and may exhibit histopathologic spectrum changes and different genetic profiles.

Although intraepithelial neoplasia showed a dichotomous pattern in the tumoral versus flat types, they can coexist.

Tumoral and flat intraepithelial neoplasia can be interpreted as part of a spectrum of changes in the carcinogenesis pathway of each organ.

Open references

- Tumoral Versus Flat Intraepithelial Neoplasia of Pancreatobiliary Tract, Gallbladder, and Ampulla of Vater.
Jang KT, Ahn S. Arch Pathol Lab Med. 2016 May;140(5):429-36.
doi : 10.5858/arpa.2015-0319-RA
PMID: 27128300 Free