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molecular pathology of pancreatobiliary cytology

Sunday 16 October 2016

molecular pathology of FNA of the pancreas

Fine-needle aspiration and bile duct brushing cytology have been traditionally used for early detection of pancreaticobiliary malignancy.

K-ras (KRAS ) mutation has a high predictive value for malignancy in patients with indeterminate pancreaticobiliary cytology and should be included as an important adjuvant diagnostic marker.

A negative K-ras mutation result does not rule out malignancy, and K-ras mutation can be detected, although infrequently, in morphologically benign conditions.

Open references

- Diagnostic value of K-ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosis. Cai G, Mahooti S, Lipata FM, Chhieng D, Hui P. Cancer Cytopathol. 2012 Oct 25;120(5):313-8. doi : 10.1002/cncy.21188
PMID: 22367918 (Free)