JNK signaling pathway
Tuesday 2 December 2003
The JNK pathway is activated by many stimuli including inflammatory factors such as IL-1 and TNF and activates c-jun transcriptional activation.
JUN (c-Jun), as part of AP-1, activates immediate early genes that are rapidly activated in response to growth factors or inflammatory signals.
Kaneto H, Matsuoka TA, Katakami N, Kawamori D, Miyatsuka T, Yoshiuchi K, Yasuda T, Sakamoto K, Yamasaki Y, Matsuhisa M. Oxidative stress and the JNK pathway are involved in the development of type 1 and type 2 diabetes. Curr Mol Med. 2007 Nov;7(7):674-86. PMID: 18045145
Bogoyevitch MA. Therapeutic promise of JNK ATP-noncompetitive inhibitors. Trends Mol Med. 2005 May;11(5):232-9. PMID: 15882611