Tuesday 2 December 2003
In skeletal muscle, insulin resistance can result from high levels of circulating fatty acids that disrupt insulin signalling pathways. However, the severity of insulin resistance varies greatly among obese people.
This variability might reflect differences in levels of lipid-droplet proteins that promote the sequestration of fatty acids within adipocytes in the form of triglycerides, thereby lowering exposure of skeletal muscle to the inhibitory effects of fatty acids. (18401346)
Cederberg A, Enerback S. Insulin resistance and type 2 diabetes—an adipocentric view. Curr Mol Med. 2003 Mar;3(2):107-25. PMID: 12630558
Shuldiner AR, Yang R, Gong DW. Resistin, obesity and insulin resistance—the emerging role of the adipocyte as an endocrine organ. N Engl J Med. 2001 Nov 1;345(18):1345-6. PMID: 11794158