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insulin resistance

Tuesday 2 December 2003

Acquired resistance to the action of insulin to stimulate glucose transport in skeletal muscle is associated with obesity and promotes the development of type 2 diabetes.

In skeletal muscle, insulin resistance can result from high levels of circulating fatty acids that disrupt insulin signalling pathways. However, the severity of insulin resistance varies greatly among obese people.

This variability might reflect differences in levels of lipid-droplet proteins that promote the sequestration of fatty acids within adipocytes in the form of triglycerides, thereby lowering exposure of skeletal muscle to the inhibitory effects of fatty acids. (18401346)


- Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol. 2008 Apr 10; PMID: 18401346

- Diamanti-Kandarakis E, Papavassiliou AG. Molecular mechanisms of insulin resistance in polycystic ovary syndrome. Trends Mol Med. 2006 Jul;12(7):324-32. PMID: 16769248

- Yki-Jarvinen H, Westerbacka J. The fatty liver and insulin resistance. Curr Mol Med. 2005 May;5(3):287-95. PMID: 15892648

- Boden G, Hoeldtke RD. Nerves, fat, and insulin resistance. N Engl J Med. 2003 Nov 13;349(20):1966-7. PMID: 14614173

- Cederberg A, Enerback S. Insulin resistance and type 2 diabetes—an adipocentric view. Curr Mol Med. 2003 Mar;3(2):107-25. PMID: 12630558

- Zick Y. Insulin resistance : a phosphorylation-based uncoupling of insulin signaling. Trends Cell Biol. 2001 Nov ;11(11):437-41. PMID : 11684411

- Shuldiner AR, Yang R, Gong DW. Resistin, obesity and insulin resistance—the emerging role of the adipocyte as an endocrine organ. N Engl J Med. 2001 Nov 1;345(18):1345-6. PMID: 11794158