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ruptured crypt granuloma

Tuesday 9 August 2016

colonic crypt rupture granuloma

Definition: Crypt-associated giant cells and granulomas can occur in ulcerative colitis and in themselves are unreliable features for the discrimination between Crohn’s disease and ulcerative colitis.

Isolated giant cells and well-defined epithelioid granulomas distant from crypts do not, as a rule, occur in ulcerative colitis, and hence their presence in a colonoscopic biopsy showing features of chronic inflammatory bowel disease is a strong pointer towards the diagnosis of Crohn’s disease.


- ulcerative colitis : ruptured crypt granuloma : mucous extravasation after cryptic dysruption

See also

- colonic granuloma
- colonic anomalies
- grnaulomas

Paywall references

- Granulomatous ulcerative colitis: a re-appraisal of the mucosal granuloma in the distinction of Crohn’s disease from ulcerative colitis.
Mahadeva U, Martin JP, Patel NK, Price AB.
Histopathology. 2002 Jul;41(1):50-5.
PMID: 12121237