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ribosomal RNA

Tuesday 2 December 2003

The mammalian ribosome is composed of 4 RNA species and approximately 80 different ribsomal proteins (RPs).

In the eukaryotic ribosomal RNA processing pathway, a complex of ten riboexonucleases called the exosome that plays a central role in the precise formation of the 3’ ends of several types of RNAs.

The exosome also destroys excess ribosomal RNA precursors and unused intermediates and degrades poly(A)-mRNAs in the cytoplasm.

In the nucleus, the complex appears to function in a regulated mRNA surveillance system that degrades transcripts in response to defects in the mRNA processing and export pathways.

Types

- cytoplasmic ribosomal RNA
- mitochondrial ribosomal RNA

References

- Moss T. At the crossroads of growth control; making ribosomal RNA. Curr Opin Genet Dev. 2004 Apr;14(2):210-7. PMID: 15196469

- Butler JS. The yin and yang of the exosome. Trends Cell Biol. 2002 Feb;12(2):90-6. PMID: 11849973