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Monday 1 December 2003


By connecting cytoskeletal elements to each other and to junctional complexes, the plakin family of cytolinkers plays a crucial role in orchestrating cellular development and maintaining tissue integrity.

Plakins are built from combinations of interacting domains that bind to microfilaments, microtubules, intermediate filaments, cell-adhesion molecules and members of the armadillo family.


- desmoplakins
- periplakin (MIM.602871)
- plectin (MIM.601282)
- BPAG1 (MIM.113810)
- envoplakin (MIM.601590)


Plakins are involved in both inherited and autoimmune diseases that affect the skin, neuronal tissue, and cardiac and skeletal muscle.


- Leung CL, Green KJ, Liem RK. Plakins: a family of versatile cytolinker proteins. Trends Cell Biol. 2002 Jan;12(1):37-45. PMID: 11854008

- Lai Cheong JE, Wessagowit V, McGrath JA. Molecular abnormalities of the desmosomal protein desmoplakin in human disease. Clin Exp Dermatol. 2005 May;30(3):261-6. PMID: 15807686