Home > A. Molecular pathology > spliceosome


Sunday 30 November 2003

Spliceosomal intron numbers and boundary sequences vary dramatically in eukaryotes.

There is a striking correspondence between low intron number and strong sequence conservation of 5’ splice sites (5’ss) across eukaryotic genomes. (#17442445#)

The phylogenetic pattern suggests that ancestral 5’ss were relatively weakly conserved, but that some lineages independently underwent both major intron loss and 5’ss strengthening. (#17442445#)

Eukaryotic ancestors had relatively large intron numbers and ’weak’ 5’ss, a pattern associated with frequent alternative splicing in modern organisms. (#17442445#)


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