Sunday 30 November 2003
Spliceosomal intron numbers and boundary sequences vary dramatically in eukaryotes.
The phylogenetic pattern suggests that ancestral 5’ss were relatively weakly conserved, but that some lineages independently underwent both major intron loss and 5’ss strengthening. (17442445)
Spliceosome mutations in hematopoietic malignancies. Hahn CN, Scott HS. Nat Genet. 2011 Dec 27;44(1):9-10. PMID: 22200771
Irimia M, Penny D, Roy SW. Coevolution of genomic intron number and splice sites. Trends Genet. 2007 Apr 17; PMID: 17442445
Roy SW, Gilbert W. The evolution of spliceosomal introns: patterns, puzzles and progress. Nat Rev Genet. 2006 Mar;7(3):211-21. PMID: 16485020
Meister G, Eggert C, Fischer U. SMN-mediated assembly of RNPs : a complex story. Trends Cell Biol. 2002 Oct ;12(10):472-8. PMID : 12441251