post-translational proteic modifications
Sunday 30 November 2003
Post-translational modifications define the functional and structural plasticity of proteins in archaea, prokaryotes and eukaryotes.
Multi-site protein modification modulates protein activity and macromolecular interactions and is involved in a range of fundamental molecular processes.
- O-linked N-acetylglucosamine (GlcNAc) glycosylation
proteic phosphorylation (PO4)
proteic carboxyl methylation by methyltransferase
endoproteolytic processing by protease
Jensen ON. Interpreting the protein language using proteomics. Nat Rev Mol Cell Biol. 2006 Jun;7(6):391-403. PMID: 16723975
Seet BT, Dikic I, Zhou MM, Pawson T. Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol. 2006 Jul;7(7):473-83. PMID: 16829979