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3-phosphoinositide

Sunday 30 November 2003

Pathology

The phosphatase and tensin homolog deleted on chromosome ten (PTEN) and myotubularin (MTM1) represent subfamilies of protein tyrosine phosphatases whose principal physiological substrates are D3-phosphorylated inositol phospholipids.

As lipid phosphatases, PTEN- and MTM1-related (MTMR) proteins dephosphorylate the products of phosphoinositide 3-kinases and antagonize downstream effectors that utilize 3-phosphoinositides as ligands for protein targeting domains or allosteric activation.

References

- Brader S, Eccles SA. Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis. Tumori. 2004 Jan-Feb;90(1):2-8. PMID: #15143962#

- Sulis ML, Parsons R. PTEN: from pathology to biology. Trends Cell Biol. 2003 Sep;13(9):478-83. PMID: #12946627#

- Wishart MJ, Dixon JE. PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. Trends Cell Biol. 2002 Dec;12(12):579-85. PMID: #12495846#

- Ali IU. Gatekeeper for endometrium: the PTEN tumor suppressor gene. J Natl Cancer Inst. 2000 Jun 7;92(11):861-3. PMID: #10841815#