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pulmonary development

Saturday 29 November 2003

Definition

Developement stages

- Embyonic (26 days-6 weeks): development of major airways
- Pseudoglandular (6-16 weeks): development of airways to terminal bronchioles
- Acinar or canalicular (16-28 weeks): development of acinus and its vascularization
- Saccular (28-34 weeks): subduvision of saccules by secondary crests
- Alveolar (34-39 weeks): alveolar acquisition (alveolarization)

Links

- Update in Pediatric Lung Disease 2009.

References

- Inanlou MR, Baguma-Nibasheka M, Kablar B. The role of fetal breathing-like movements in lung organogenesis. Histol Histopathol. 2005 Oct;20(4):1261-6. PMID: #16136506#

- Warburton D, Bellusci S, De Langhe S, Del Moral PM, Fleury V, Mailleux A, Tefft D, Unbekandt M, Wang K, Shi W. Molecular mechanisms of early lung specification and branching morphogenesis. Pediatr Res. 2005 May;57(5 Pt 2):26R-37R. PMID: #15817505#

- Groenman F, Unger S, Post M. The molecular basis for abnormal human lung development. Biol Neonate. 2005;87(3):164-77. PMID: #15591817#

- Hislop A. Developmental biology of the pulmonary circulation. Paediatr Respir Rev. 2005 Mar;6(1):35-43. PMID: #15698814#

- Shannon JM, Hyatt BA. Epithelial-mesenchymal interactions in the developing lung. Annu Rev Physiol. 2004;66:625-45. PMID: #14977416#

- Chuang PT, McMahon AP. Branching morphogenesis of the lung: new molecular insights into an old problem. Trends Cell Biol. 2003 Feb;13(2):86-91. PMID: #12559759#

- DiFiore JW, Wilson JM. Lung development. Semin Pediatr Surg. 1994 Nov;3(4):221-32. PMID: #7850362#

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