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Saturday 29 November 2003

Vinculin is a cytoskeletal protein associated with the cytoplasmic face of both cell-cell and cell-extracellular matrix adherens-type junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane.


- germline mutations of VCL in dilated cardiomyopathy (CMD1W) (MIM.611407)

See also

- TLNs: TLN1, TLN2
- ITGs
- VILs: VIL1, VIL2


- Bailly M. Connecting cell adhesion to the actin polymerization machinery: vinculin as the missing link? Trends Cell Biol. 2003 Apr;13(4):163-5. PMID: 12667752