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therapy-related myeloid neoplasms

Monday 11 April 2016

t-MN

Deletion 7q is a common chromosomal abnormality in patients with therapy-related myeloid neoplasms (t-MN). Newly emerged del(7q) in patients with prior cytotoxic therapies raises concern for t-MN.

del(7q) emerged in patients with prior cytotoxic therapies is not always associated with t-MN. The clone size is critical. When del(7q) presents as a major clone it is often associated with t-MN; whereas when it is a minor clone it may be a transient finding and may not have any clinical significance.

Close follow-up rather than an immediate therapeutic intervention seems most appropriate for those patients with a minor clone of del(7q) in BM.

Reference

- Abstract USCAP 2016 https://twitter.com/feldstej/status/709730323668402176