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Home > E. Pathology by systems > Digestive system > Liver and pancreatobiliary system > Liver > lymphoepithelioma-like hepatocellular carcinoma

lymphoepithelioma-like hepatocellular carcinoma

Monday 23 February 2015

Lymphoepithelioma-like hepatocellular carcinoma (LEL-HCC) is an uncommon variant of HCC with only 22 cases reported in the literature in 2014.

LEL-HCC is an independent prognostic factor for overall and progression-free survivals.

LEL-HCC does not differ in frequencies of microsatellite instability, BRAF mutation, and DNA hypermethylation.

LEL-HCC is a distinct uncommon variant of HCC characterized by dense cytotoxic T-cell infiltration and favorable prognosis.


- Lymphoepithelioma-like Hepatocellular Carcinoma: An Uncommon Variant of Hepatocellular Carcinoma With Favorable Outcome. Chan AW, Tong JH, Pan Y, Chan SL, Wong GL, Wong VW, Lai PB, To KF. Am J Surg Pathol. 2015 Mar;39(3):304-12. doi : 10.1097/PAS.0000000000000376 PMID: 25675010