- Human pathology

Home > D. General pathology > Therapy, Toxics and drugs > clofazimine


Wednesday 18 May 2016


Clofazimine is a fat-soluble riminophenazine dye used in combination with rifampicin and dapsone as multidrug therapy (MDT) for the treatment of leprosy.

It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients and Mycobacterium avium paratuberculosis infection in Crohn’s disease patients. The drug is given as an alternative to patients who can not tolerate the effects of dapsone for tuberculosis.

Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum (ENL).


- clofazimine-induced histiocytosis (10632497)


- Intra-abdominal, crystal-storing histiocytosis due to clofazimine in a patient with lepromatous leprosy and concurrent carcinoma of the colon. Pais AV, Pereira S, Garg I, Stephen J, Antony M, Inchara YK. Lepr Rev. 2004 Jun;75(2):171-6. PMID: 15282969

- Clofazimine-induced crystal-storing histiocytosis producing chronic abdominal pain in a leprosy patient. Sukpanichnant S, Hargrove NS, Kachintorn U, Manatsathit S, Chanchairujira T, Siritanaratkul N, Akaraviputh T, Thakerngpol K. Am J Surg Pathol. 2000 Jan;24(1):129-35. PMID: 10632497