- Human pathology

Home > E. Pathology by systems > Respiratory system > Pleura > pleural atypical mesothelial hyperplasia

pleural atypical mesothelial hyperplasia

Monday 5 January 2015

DIfferential diagnosis

An indeterminate biopsy showing severely atypical mesothelial hyperplasia, in the background of occupational exposure to asbestos, clinical, radiographic, or gross findings compatible with MM, should prompt the surgical pathologist to phrase the final diagnosis as “atypical mesothelial hyperplasia without diagnostic features of malignancy, however, mesothelioma cannot be excluded with confidence.” This leads the clinician to consider what, if any, diagnostic tests must be done next.

Adequate sampling is the best way to avoid this awkward situation for the surgeon, pathologist, and most importantly, the patient, who may not understand why an invasive procedure did not yield a definitive diagnosis. But unfortunately, even under the best of circumstances, the definitive diagnosis of MM can be elusive.

See also

- mesothelial proliferations