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cystitis glandularis

Tuesday 21 October 2014

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Definition: Brunn nests, cystitis cystica and cystitis glandularis are reactive urothelial changes commonly encountered in bladder specimens.

Cystitis cystica et glandularis refers to Brunn’s nests in the lamina propria with cystic spaces, and other glands with cuboidal to columnar epithelium, as seen here. Intestinal type contains Goblet cells.

Brunn nests are invaginations from the overlying urothelium into the lamina propria.

When Brunn nests become cystically dilated (with or without eosinophilic secretions in the lumen) - this change is referred to as cystitis cystica.

When the urothelial cell nests show a central lumen lined by glandular epithelium, it is referred to as cystitis glandularis.

Most areas of cystitis cystica and cystitis glandularis are microscopic. In some cases, florid cystitis cystica and cystitis glandularis may form polypoid masses that clinically mimic urothelial neoplasia.

Images

- Reactive Atypical Low Columnar/Cuboidal cells of Cystitis Glandularis in Urine Cytology

- Cystitis glandularis with intestinal metaplasia