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intestinal metaplasia of the bladder mucosa

Tuesday 21 October 2014

PO

Definition: Replacement of urothelium by colonic mucosa or isolated / clusters of goblet cells in Brunn nests.

Macroscopy

- Irregular rounded focal elevations of mucosa
- Rarely polypoidal with mucinous extravasations

Microscopy

- Replacement of urothelium by colonic mucosa (tall columnar cells)
- Also goblet cells (single or aggregates) within Brunn’s nests, variable presence of Paneth cells
- May coexist with cystitis cystica or cystitis glandularis
- Mucin may be occasionally extravasated into the stroma
- No atypia, no involvement of muscularis propria

See also

- cystitis cystica / cystitis glandularis