Home > E. Pathology by systems > Skin > atypical fibroxanthoma
atypical fibroxanthoma
Sunday 5 October 2014
AFX ; atypical fibrous xanthoma
| PO |
Synopsis
subcutaneous nodule
highly atypical cells with nuclear enlargement, pleomorphism, hyperchromasia
bizarre cells
multinucleated giant cells
vacuolisation
Image
atypical fibroxanthoma / AFX
- https://twitter.com/cassarino_david/status/720493861169164290
- https://twitter.com/LIvkovski/status/1421003994189664256
- https://twitter.com/PIorfino/status/1500836894829170688
Pitfalls
Digital case
JRC:11035 : Atypical fibrous xanthoma.
IHC
IHC+
- CD10+
- Vimentin+, CD68+, alpha-1-antitrypsin+, alpha-1-antichymotrypsin+, Factor XIIIa+ (focal)
- CD117+*), CD99+ (73%), CD10+
- D2-40+ (50%), calponin+ (30%), desmin+ (30%), smooth muscle actin+ (30%)
Differential diagnosis
- dermatofibrosarcoma protuberans
- angiosarcomas : spindle cell angiosarcoma
- atypical fibrous histiocytoma
desmoplastic melanoma
- may have focal AFX-type features and stain negative for melanocytic markers (Am J Dermatopathol 2007;29:551)
fusiform cell squamous cell carcinoma / spindle cell type: deep extension, p63+
Videos :
Atypical fibroxanthoma (AFX) vs other cutaneous pleomorphic spindle cell tumors. https://youtu.be/zdWFmSoouXM
See also
fibrous xanthoma
