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atypical fibroxanthoma
Sunday 5 October 2014
AFX ; atypical fibrous xanthoma
| PO |
Image
atypical fibroxanthoma / AFX
Pitfalls
Digital case
JRC:11035 : Atypical fibrous xanthoma.
IHC
IHC+
- Vimentin+, CD68+, alpha-1-antitrypsin+, alpha-1-antichymotrypsin+, Factor XIIIa+ (focal)
- CD117+*), CD99+ (73%), CD10+
- D2-40+ (50%), calponin+ (30%), desmin+ (30%), smooth muscle actin+ (30%)
Differential diagnosis
dermatofibrosarcoma protuberans
angiosarcomas : spindle cell angiosarcoma
atypical fibrous histiocytoma
desmoplastic melanoma
- may have focal AFX-type features and stain negative for melanocytic markers (Am J Dermatopathol 2007;29:551)
squamous cell carcinoma-spindle cell type: deep extension, p63+
Videos :
Atypical fibroxanthoma (AFX) vs other cutaneous pleomorphic spindle cell tumors. https://youtu.be/zdWFmSoouXM
See also
fibrous xanthoma
