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atypical fibroxanthoma

Sunday 5 October 2014

AFX ; atypical fibrous xanthoma

PO

Image

- atypical fibroxanthoma / AFX

- Pitfalls

Digital case

- JRC:11035 : Atypical fibrous xanthoma.

IHC

- IHC+

  • Vimentin+, CD68+, alpha-1-antitrypsin+, alpha-1-antichymotrypsin+, Factor XIIIa+ (focal)
  • CD117+*), CD99+ (73%), CD10+
  • D2-40+ (50%), calponin+ (30%), desmin+ (30%), smooth muscle actin+ (30%)

Differential diagnosis

- dermatofibrosarcoma protuberans
- angiosarcomas : spindle cell angiosarcoma
- atypical fibrous histiocytoma
- desmoplastic melanoma

  • may have focal AFX-type features and stain negative for melanocytic markers (Am J Dermatopathol 2007;29:551)

- squamous cell carcinoma-spindle cell type: deep extension, p63+

Videos :

- Atypical fibroxanthoma (AFX) vs other cutaneous pleomorphic spindle cell tumors. https://youtu.be/zdWFmSoouXM

See also

- fibrous xanthoma