Humpath.com - Human pathology

Home > G. Tumoral pathology > Molecular pathology of tumors > Ovarian mucinous tumors (molecular pathology)

Ovarian mucinous tumors (molecular pathology)

Wednesday 10 September 2014

Mucinous Tumors

Ovarian mucinous tumors have been the least studied histologic types probably due to their relative rarity (approximately 3% of EOC).

KRAS mutations occur in up to 75% of primary mucinous carcinomas and using KRAS as a molecular marker, laser capture microdissection studies have shown the identical KRAS mutation in mucinous carcinomas and adjacent mucinous cystadenomas and borderline tumors supporting the morphological continuum and tumor progression in ovarian mucinous neoplasms.

Credits

- Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—shifting the paradigm. Kurman RJ, Shih IeM. Hum Pathol. 2011 Jul;42(7):918-31. doi : 10.1016/j.humpath.2011.03.003 PMID: 21683865 (Free)