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Interstitial fibroblastic foci

Wednesday 20 August 2014

fibroblastic foci

- Interstitial fibroblastic foci are circumscribed nodules of fibroblastic proliferation and immature connective tissue.

  • Fibroblastic foci, consisting of proliferation of immature fibrous connective tissue at the periphery of an air space, are a characteristic finding in UIP and are indicative of disease activity.
  • They may sometimes be found in other types of interstitial pneumonia.
  • Temporal heterogeneity, patchy low power appearance and fibroblastic foci are important diagnostic features of UIP.