silica-associated microscopic polyangiitis
Wednesday 15 January 2014
Microscopic polyangiitis secondary to silica exposure
There is sufficient evidence of the capacity of silica to induce autoimmunity in patients with some type of genetic susceptibility.
There are several autoimmune diseases related to this exposure (rheumatoid arthritis, Sjögren’s syndrome, sarcoidosis, systemic sclerosis).
Nodular silicosis (clinical expression of this exposure in lungs) generates apoptosis, inflammation, loss of tolerance and a respiratory burst.
There is evidence that relates silica with induction of antineutrophil cytoplasmic antibodies, but, until it is better explained, the reports of systemic vasculitis secondary to silica exposure are inconclusive.
Microscopic polyangiitis secondary to silica exposure. Vega Miranda J, Pinto Peñaranda LF, Márquez Hernández JD, Velásquez Franco CJ. Reumatol Clin. 2013 Jul 22. pii: S1699-258X(13)00103-4. doi:10.1016/j.reuma.2013.04.009 . PMID: 23886979 [Free]