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mammary analogue secretory carcinoma of salivary glands

Wednesday 15 January 2014

Mammary Analogue Secretory Carcinoma of Salivary Glands; mammary analogue secretory carcinoma of salivary gland origin (MASC)

Definition: Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a tumor resembling secretory carcinoma of the breast characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression. It harbors a t(12;15) (p13;q25) translocation resulting in ETV6-NTRK3 fusion product.

Histologically, conventional MASC displays bland histomorphology and a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogenous or bubbly secretions.

Colloid-like secretory material stains positively for periodic acid-Schiff with and without diastase as well as for Alcian Blue.

References

- Mammary Analogue Secretory Carcinoma of Salivary Glands: A Clinicopathologic and Molecular Study Including 2 Cases Harboring ETV6-X Fusion. Ito Y, Ishibashi K, Masaki A, Fujii K, Fujiyoshi Y, Hattori H, Kawakita D, Matsumoto M, Miyabe S, Shimozato K, Nagao T, Inagaki H. Am J Surg Pathol. 2015 Feb 3. PMID: 25651470

- Mammary Analogue Secretory Carcinoma of Salivary Glands With High-grade Transformation: Report of 3 Cases With the ETV6-NTRK3 Gene Fusion and Analysis of TP53, β-Catenin, EGFR, and CCND1 Genes. Skálová A, Vanecek T, Majewska H, Laco J, Grossmann P, Simpson RH, Hauer L, Andrle P, Hosticka L, Branžovský J, Michal M. Am J Surg Pathol. 2014 Jan;38(1):23-33. doi : 10.1097/PAS.0000000000000088 PMID: 24145651

- Mammary analogue secretory carcinoma of salivary glands is a lipid-rich tumour, and adipophilin can be valuable in its identification. Mariano FV, Dos Santos HT, Azañero WD, da Cunha IW, Coutinho-Camilo CM, de Almeida OP, Kowalski LP, Altemani A.
Histopathology. 2013 May 17. doi : 10.1111/his.12192 PMID: 23931576