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miR-1246

Thursday 9 January 2014

Pathology

- lung cancer

  • The microRNA-1246 promotes metastasis in non-small cell lung cancer by targeting cytoplasmic polyadenylation element-binding protein 4. (26209100)
  • miR-1246 may promote cell metastasis by targeting CPEB4.
  • Meanwhile, the level of CPEB4 could be used as a potential marker in NSCLC patients.

- oesophageal squamous cell carcinoma (OSCC)

  • miR-1246 is a diagnostic and prognostic biomarker for oesophageal squamous cell carcinoma. (23361059)

Open references

- The microRNA-1246 promotes metastasis in non-small cell lung cancer by targeting cytoplasmic polyadenylation element-binding protein 4. Huang W, Li H, Luo R. Diagn Pathol. 2015 Jul 25;10:127. doi : 10.1186/s13000-015-0366-1 PMID: 26209100 (Free)

References

- Serum microRNA expression profile: miR-1246 as a novel diagnostic and prognostic biomarker for oesophageal squamous cell carcinoma. Takeshita N, Hoshino I, Mori M, Akutsu Y, Hanari N, Yoneyama Y, Ikeda N, Isozaki Y, Maruyama T, Akanuma N, Komatsu A, Jitsukawa M, Matsubara H. Br J Cancer. 2013 Feb 19;108(3):644-52. doi : 10.1038/bjc.2013.8 PMID: 23361059