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CTCs competent for metastasis

Sunday 5 January 2014

Tumors

- breast cancer

  • The identification and characterization of breast cancer CTCs competent for brain metastasis. (23576814)
  • Brain metastatic breast cancer (BMBC) is uniformly fatal and increasing in frequency.
  • Despite its devastating outcome, mechanisms causing BMBC remain largely unknown. The mechanisms that implicate circulating tumor cells (CTCs) in metastatic disease, notably in BMBC, remain elusive.

Open references

- The identification and characterization of breast cancer CTCs competent for brain metastasis. Zhang L, Ridgway LD, Wetzel MD, Ngo J, Yin W, Kumar D, Goodman JC, Groves MD, Marchetti D. Sci Transl Med. 2013 Apr 10;5(180):180ra48. doi : 10.1126/scitranslmed.3005109 PMID: 23576814 [Free]