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PLS3

Sunday 5 January 2014

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Definition: Plastin-3 is a highly-conserved protein that in humans is encoded by the PLS3 gene on the X chromosome.

Pathology

- PLS3 variants

- Colorectal cancer

  • Aberrant Expression of Plastin-3 Via Copy Number Gain Induces the Epithelial-Mesenchymal Transition in Circulating Colorectal Cancer Cells. PMID: 24217791
  • Plastin polymorphisms predict gender and stage-specific colon cancer recurrence after adjuvant chemotherapy. PMID: 24170770
  • A common gene variant in PLS3 predicts colon cancer recurrence in women. PMID: 23549633
  • Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis. PMID: 23378342

- Sezary syndrome

  • Use of PLS3, Twist, CD158k/KIR3DL2, and NKp46 gene expression combination for reliable Sézary syndrome diagnosis. PMID : 23429988
  • T-plastin (PLS3) gene expression differentiates Sézary syndrome from mycosis fungoides and inflammatory skin diseases and can serve as a biomarker to monitor disease progression. PMID: 19995369