Home > A. Molecular pathology > PLS3

PLS3

Sunday 5 January 2014

WP

Definition: Plastin-3 is a highly-conserved protein that in humans is encoded by the PLS3 gene on the X chromosome.

Pathology

- PLS3 variants

  • Defects in PLS3 are associated with osteoporosis and bone fracture in humans and in knockout zebrafish.

- Colorectal cancer

  • Aberrant Expression of Plastin-3 Via Copy Number Gain Induces the Epithelial-Mesenchymal Transition in Circulating Colorectal Cancer Cells. PMID: #24217791#
  • Plastin polymorphisms predict gender and stage-specific colon cancer recurrence after adjuvant chemotherapy. PMID: #24170770#
  • A common gene variant in PLS3 predicts colon cancer recurrence in women. PMID: #23549633#
  • Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis. PMID: #23378342#

- Sezary syndrome

  • Use of PLS3, Twist, CD158k/KIR3DL2, and NKp46 gene expression combination for reliable Sézary syndrome diagnosis. PMID : #23429988#
  • T-plastin (PLS3) gene expression differentiates Sézary syndrome from mycosis fungoides and inflammatory skin diseases and can serve as a biomarker to monitor disease progression. PMID: #19995369#