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miRNAs in colorectal cancer

Sunday 5 January 2014

Notes

- MicroRNAs (or miRNAs) are small transcripts of 20-24 nucleotides that have emerged as important regulators of gene expression in cancer cells.
- Overexpression of specific miRNAs has been linked to the stepwise disease progression during the normal-adenoma-cancer sequence in the colorectal cancer (CRC).
- Given their cancer-specific pattern of expression, remarkable stability and presence in blood and other body fluids, miRNAs are considered to be highly promising cancer biomarkers.

- Some infrequently expressed miRNAs, when expressed at higher levels, appear to have significant biological meaning in terms of tumor molecular phenotype and gene expression profiles. (28548123)

Open references

- Infrequently expressed miRNAs in colorectal cancer tissue and tumor molecular phenotype. Slattery ML, Lee FY, Pellatt AJ, Mullany LE, Stevens JR, Samowitz WS, Wolff RK, Herrick JS. Mod Pathol. 2017 Aug;30(8):1152-1169. doi : 10.1038/modpathol.2017.38 PMID: 28548123 Free

- Gaedche, J., Grade, M., Camps, J. et al. July 31, 2012. The Rectal Cancer microRNAome - microRNA Expression in Rectal Cancer and Matched Normal Mucosa. Clin Cancer Res. 2012 Sep 15;18(18):4919-30. PMID: 22850566 [Free]