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TRIM24-BRAF

Saturday 4 January 2014

- PAPSS1-BRAF and TRIM24-BRAF fusion gene in melanoma

  • BRAF fusions define a new molecular subset of melanoma, potentially comprising 4% to 8% of "pan-negative" cases.
  • Their presence may explain an unexpected clinical response to MEK inhibitor therapy or assist in selecting patients for MEK-directed therapy.

References

- BRAF Fusions Define a Distinct Molecular Subset of Melanomas with Potential Sensitivity to MEK Inhibition. Hutchinson KE, Lipson D, Stephens PJ, Otto G, Lehmann BD, Lyle PL, Vnencak-Jones CL, Ross JS, Pietenpol JA, Sosman JA, Puzanov I, Miller VA, Pao W. Clin Cancer Res. 2013 Dec 15;19(24):6696-702. doi:10.1158/1078-0432.CCR-13-1746 . PMID: #24345920#