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AMY1A

Monday 2 December 2013

Immunochemistry

- Amylase α-1A (AMY1A) differentiate Chromophobe Renal Cell Carcinoma from Benign Oncocytoma. (#24225843#)

  • Chromophobe renal cell carcinoma (ChRCC) and oncocytoma present with a perplexing overlap of morphologic and immunohistochemical features.
  • ChRCC have deletions in the 1p21.1 region including the amylase α-1A gene (AMY1A).
  • No such deletions are found in oncocytoma. Instead, oncocytomas shared other deletions on chromosome 1: 1p31.3, 1q25.2, and 1q44.
  • AMY1A can be of great diagnostic utility when trying to differentiate ChRCC (classic and eosinophilic variant) and oncocytoma.

References

- Amylase α-1A (AMY1A): A Novel Immunohistochemical Marker to Differentiate Chromophobe Renal Cell Carcinoma From Benign Oncocytoma. Jain S, Roy S, Amin M, Acquafondata M, Yin M, Laframboise W, Bastacky S, Pantanowitz L, Dhir R, Parwani A.
Am J Surg Pathol. 2013 Dec;37(12):1824-30. doi:10.1097/PAS.0000000000000108 . PMID: #24225843#