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synovial chondromatosis

Tuesday 15 October 2013

synovial osteochondromatosis, primary synovial osteochondromatosis, synovial chondrometaplasia; Reichel’s syndrome or Reichel-Jones-Henderson syndrome, named after Friedrich Paul Reichel, Hugh Toland Jones and Melvin Starkey Henderson.


Definition: Synovial chondromatosis is a disease affecting the synovium, a thin flexible membrane around a joint.


- chondroid metaplasia in chronic synovitis


- Synovial Chondromatosis: hyaline nodules; myxoid degeneration; +/- hypercellularity; binucleation

- intra-articular synovial chondromatosis

- macroscopy

- radiology


- Numerous round osteocartilaginous nodules cover a thickened synovial surface or float freely within joint space.
- Cartilage cells with variable atypia or binucleated forms within synovium ;
- clusters of chondrocytes are often arranged in lobules;
- no underlying arthritis
- hyaline nodules
- myxoid degeneration
- +/- hypercellularity
- binucleation

Differential diagnosis

- cartilaginous loose bodies : more common, but associated with arthritis
- chondrosarcoma: not within a joint, no characteristic clustering pattern, marked myxoid change, spindling of nuclei
- injury-related soft-tissue calcification
- arborescent lipoma with osseous metaplasia
- neuropathic arthropathy or osteochondritis dissecans : no lobulation, clustering or atypia
- pigmented villonodular synovitis
- secondary synovial chondrometaplasia due to degenerative joint disease
-synovial vascular malformation

Secondary disease

Associated with degenerative joint disease - growth of fragments of articular cartilage

Initially intrasynovial disease without loose bodies; then intrasynovial proliferation and free loose bodies, then multiple free osteochondral bodies without intrasynovial disease. No atypia.

See also

- chondromatosis
- synovial anomalies