Monday 14 October 2013
Intravenous leiomyomatosis (IVL) is a rare smooth-muscle proliferation that is of special interest because of its quasi-malignant behavior.
Intravascular leiomyomatosis (IVL) is characterized by the presence of smooth muscle in venous and lymphatic spaces within the myometrium.
Although the intravascular component usually consists solely of typical smooth muscle or variants of smooth muscle differentiation, some cases have been reported in which the intravascular component also included endometrioid glandular and stromal elements. The term "intravenous adenomyomatosis" to describe this unusual variant of IVL.
t(12;14)(q15;q24) (#11904348#, #12508249#)
- IVL could arise from a uterine leiomyoma with a t(12;14)(q15;q24)
- peritoneal leiomyomatosis
Intravascular adenomyomatosis: expanding the morphologic spectrum of intravascular leiomyomatosis. Hirschowitz L, Mayall FG, Ganesan R, McCluggage WG. Am J Surg Pathol. 2013 Sep;37(9):1395-400. doi:10.1097/PAS.0b013e31828b2c99 . PMID: #24076777#
Dal Cin P, Quade BJ, Neskey DM, Kleinman MS, Weremowicz S, Morton CC. Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24). Genes Chromosomes Cancer. 2003 Feb;36(2):205-6. PMID: #12508249#
Quade BJ, Dal Cin P, Neskey DM, Weremowicz S, Morton CC. Intravenous leiomyomatosis: molecular and cytogenetic analysis of a case. Mod Pathol. 2002 Mar;15(3):351-6. PMID: #11904348#