- Human pathology

Home > F. Pathology by regions > Head and neck > Head > Nose and sinonasal cavity > respiratory epithelial adenomatoid hamartoma

respiratory epithelial adenomatoid hamartoma

Monday 14 October 2013

Respiratory epithelial adenomatoid hamartoma (REAH)

Definition: Respiratory epithelial adenomatoid hamartoma (REAH) is regarded as a rare tumor of the nasal cavity. The mechanisms driving the development of REAH are unknown, and its nature as a benign tumor, hamartoma, or reactive inflammatory process is still open to discussion.

If solitary REAH is a relatively rare lesion, it has been demonstrated that an exhaustive sampling allows the detection of a high proportion of nasal polyposis-associated REAH, sharing the same clinical and histologic characteristics with solitary REAH.

Tryptase-producing MCs, possibly in association with MMP expression, may play a central role in REAH formation.


- Respiratory Epithelial Adenomatoid Hamartoma: A Poorly Recognized Entity With Mast Cell Recruitment and Frequently Associated With Nasal Polyposis. doi : 10.1097/PAS 0000000000000092