Saturday 12 October 2013
MicroRNAs (miRNAs) are a class of small non-coding RNAs, which are negative regulators of gene expression.
- Many genes in human uterine leiomyoma (ULM) are aberrantly expressed and in some cases this can be due to dysregulation of miRNAs.
- More than 50 miRNAs are differentially expressed.
- The top five significantly de-regulated miRNAs in ULMs are miR-363, miR-490, miR-137, miR-217 and miR-4792.
- Some authors also observed "isomiRs" with higher copy number than referenced mature miRNA specific for the leiomyoma libraries, which have a potential role in tumorigenesis.
Gaedche, J., Grade, M., Camps, J. et al. July 31, 2012. The Rectal Cancer microRNAome - microRNA Expression in Rectal Cancer and Matched Normal Mucosa. Clinical Cancer Research.
Characterization of the uterine leiomyoma microRNAome by deep sequencing. Georgieva B, Milev I, Minkov I, Dimitrova I, Bradford AP, Baev V. Genomics. 2012 May;99(5):275-81. doi : 10.1016/j.ygeno.2012.03.003 PMID: 22446413
Micromanaging the classification of colon cancer: the role of the microRNAome. Vilar E, Tabernero J, Gruber SB. Clin Cancer Res. 2011 Dec 1;17(23):7207-9. doi : 10.1158/1078-0432.CCR-11-2440 PMID: 22019515 [Free]