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miRNome

Saturday 12 October 2013

microRNAome; microRNAomics

MicroRNAs (miRNAs) are a class of small non-coding RNAs, which are negative regulators of gene expression.

Pathology

- uterine leiomyoma (#22446413#)

  • Many genes in human uterine leiomyoma (ULM) are aberrantly expressed and in some cases this can be due to dysregulation of miRNAs.
  • More than 50 miRNAs are differentially expressed.
  • The top five significantly de-regulated miRNAs in ULMs are miR-363, miR-490, miR-137, miR-217 and miR-4792.
  • Some authors also observed "isomiRs" with higher copy number than referenced mature miRNA specific for the leiomyoma libraries, which have a potential role in tumorigenesis.

Reference

- Gaedche, J., Grade, M., Camps, J. et al. July 31, 2012. The Rectal Cancer microRNAome - microRNA Expression in Rectal Cancer and Matched Normal Mucosa. Clinical Cancer Research.

- Characterization of the uterine leiomyoma microRNAome by deep sequencing. Georgieva B, Milev I, Minkov I, Dimitrova I, Bradford AP, Baev V. Genomics. 2012 May;99(5):275-81. doi: 10.1016/j.ygeno.2012.03.003. PMID: #22446413#

- Micromanaging the classification of colon cancer: the role of the microRNAome. Vilar E, Tabernero J, Gruber SB. Clin Cancer Res. 2011 Dec 1;17(23):7207-9. doi:10.1158/1078-0432.CCR-11-2440. PMID: #22019515# [Free]