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squamous metaplasia

Wednesday 28 August 2013


Definition: Squamous metaplasia refers to benign non-cancerous change (metaplasia) of (non-squamous) surfacing lining cells (epithelium) to a squamous morphology.

Common sites for squamous metaplasia include the bladder and cervix. Smokers often exhibit squamous metaplasia in the linings of their airways. These changes don’t signify a specific disease, but rather usually represent the body’s response to stress or irritation. Vitamin A deficiency can lead to squamous metaplasia.

Squamous metaplasia may be seen in the context of benign lesions (e.g. atypical polypoid adenomyoma), chronic irritation or cancer (e.g. endometrioid endometrial carcinoma).


- bronchial squamous metaplasia
- cervical squamous metaplasia
- biliary squamous metaplasia in extrahepatic bile duct
- vesical squamous metaplasia


- Squamous metaplasia of extrahepatic bile duct

- Wikimedia: immature squamous metaplasia of the anus.

See also

- squamous epithelium / stratified epithelium
- squamous differenciation

-  epithelial anomalies