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benign Brenner tumor

Thursday 25 July 2013

benign Brenner tumor of the ovary; ovarian benign Brenner tumor



- Benign Brenner tumor of the ovary : Macroscopy : Usually unilateral, gritty, firm

- Benign Brenner tumor of the ovary : Microscopy


- The Brenner tumors are composed of solid and cystic nests of epithelium resembling transitional epithelium in a dense fibroblastic stroma.
- The transitional epithelial cells have sharply defined outlines, oval nuclei with longitudinal grooves, and small or inconspicuous nucleoli.
- Nests of transitional cells with pale cytoplasm scattered in a dense stroma.
- The stromal component usually resembles an ovarian fibroma and may contain luteinized cells.
- Estrogen secretion by stromal cells may occasionally result in endocrine manifestations.
- Irregular nests of benign transitional (urothelial) cells are scattered in dense hyalinized stroma in this benign Brenner tumor.
- Brenner tumor may have small or large cysts. Often, these cysts are lined by mucinous epithelium beneath which are transitional epithelium-type cells.

See also

- transitionnal cell tumors
- ovarian tumors