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adult T-cell lymphoma/leukemia with angioimmunoblastic T-cell lymphoma-like features

Wednesday 24 July 2013

ATCLL with angioimmunoblastic T-cell lymphomalike features

Definition: In adult T-cell lymphoma/leukemia (ATLL), the neoplastic lymphoid cells are usually medium-sized to large, often with pronounced nuclear pleomorphism compatible with the diagnosis of diffuse pleomorphic peripheral T-cell lymphoma. Some patients have a rare morphologic variant of ATLL, of angioimmunoblastic T-cell lymphoma (AILT)-like type.

Synopsis

- proliferation of high endothelial venules
- various infiltrating inflammatory cells including plasma cells and eosinophils.
- The lymphoma cells are medium-to-large size with clear cytoplasm.

References

- Adult T-cell lymphoma/leukemia with angioimmunoblastic T-cell lymphomalike features: Report of 11 cases. Karube K, Suzumiya J, Okamoto M, Takeshita M, Maeda K, Sakaguchi M, Inada T, Tsushima H, Kikuchi M, Ohshima K. Am J Surg Pathol. 2007 Feb;31(2):216-23. PMID: 17255766