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clonally related follicular lymphomas and langerhans cell histiocytosis

Monday 15 July 2013

Clonally related follicular lymphomas and langerhans cell neoplasms

The traditional model of hematopoiesis is based on unidirectional maturation of hematopoietic precursors into lineage-committed cells. However, recent studies indicate that mature B lymphocytes may demonstrate significant lineage plasticity.

Some authors have reported transdifferentiation of follicular lymphomas (FLs) into clonally related histiocytic/dendritic cell neoplasms.

These cases provide striking examples of neoplastic transdifferentiation and expand the spectrum of lesions clonally identical to otherwise typical FL.

Awareness of this phenomenon may aid in diagnosis when histologically dissimilar tumors arise synchronously or metachronously in patients with lymphoma.

References

- Clonally related follicular lymphomas and langerhans cell neoplasms: expanding the spectrum of transdifferentiation. West DS, Dogan A, Quint PS, Tricker-Klar ML, Porcher JC, Ketterling RP, Law ME, McPhail ED, Viswanatha DS, Kurtin PJ, Dao LN, Ritzer RD, Nowakowski GS, Feldman AL. Am J Surg Pathol. 2013 Jul;37(7):978-86. doi : 10.1097/PAS.0b013e318283099f PMID: 23759932